Hydrochloric Acid → 4-Nitrophenylglyoxylic acid
反応式
[OH-].[Na+].[N+:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:18])[C:13]([O:15]CC)=[O:14])=[CH:8][CH:7]=1)([O-:5])=[O:4].Cl>CO>[N+:3]([C:6]1[CH:7]=[CH:8][C:9]([C:12](=[O:18])[C:13]([OH:15])=[O:14])=[CH:10][CH:11]=1)([O-:5])=[O:4]参加物
5
実験手順
3 ml (6 mmol) of a 2N aqueous solution of sodium hydroxide were added to a solution of 651 mg (2.92 mmol) of ethyl 4-nitrophenylglyoxylate in methanol, and the resulting mixture was stirred overnight at room temperature. The reaction mixture was poured into 2N hydrochloric acid and extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. The solvent was distilled off, to give 0.8 g (quantitative yield) of 4-nitrophenylglyoxylic acid as a crude product.
後処理
- extractionextracted with ethyl acetate
- washThe extract was washed with a saturated aqueous solution of sodium chloride
- dry with materialdried over anhydrous magnesium sulfate
- distillationThe solvent was distilled off
出典と根拠
- ORDレコード
- ord-587bf9f0a6bd441ab99c77d1234c0af4
- 出典データセット
- uspto-grants-1997_03
- 特許番号
- US05614470
反応ノート
読み込み中…