Ethyl 4-methyl-2-(4-(4-methylpiperazinyl)-3-nitrophenyl)-5-thiazolecarboxylate → HCID 19965093、化合物

HRID 977103ノート

反応式

HRID 977103 の反応式
ClC1C=CC(C2SC(C(OCC)=O)=C(C)N=2)=CC=1[N+]([O-])=O.[CH3:22][C:23]1[N:24]=[C:25]([C:33]2[CH:38]=[CH:37][C:36]([N:39]3[CH2:44][CH2:43][N:42]([CH3:45])[CH2:41][CH2:40]3)=[C:35]([N+:46]([O-:48])=[O:47])[CH:34]=2)[S:26][C:27]=1[C:28]([O:30]CC)=[O:29]>CN1CCNCC1>[CH3:22][C:23]1[N:24]=[C:25]([C:33]2[CH:38]=[CH:37][C:36]([N:39]3[CH2:40][CH2:41][N:42]([CH3:45])[CH2:43][CH2:44]3)=[C:35]([N+:46]([O-:48])=[O:47])[CH:34]=2)[S:26][C:27]=1[C:28]([OH:30])=[O:29]

参加物

4

反応物 2

HCID 19965166Ethyl 4-methyl-2-(4-(4-methylpiperazinyl)-3-nitrophenyl)-5-thiazolecarboxylateHCID 19965170Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate

生成物 1

HCID 19965093HCID 19965093、化合物収率 58%

試薬・触媒・溶媒 1

HCID 531671-Methylpiperazine溶媒

実験手順

As described in Example 37, ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate was reacted in 1-methylpiperazine, and the resulting ethyl 4-methyl-2-(4-(4-methylpiperazinyl)-3-nitrophenyl)-5-thiazolecarboxylate was hydrolyzed by a conventional process to give 4-methyl-2-(4-(4-methylpiperazinyl)-3-nitrophenyl)-5-thiazolecarboxylic acid (yield: 58%).

出典と根拠

ORDレコード
ord-b79b11818ac64e6fb4a8c87188d97185
出典データセット
uspto-grants-1997_03
特許番号
US05614520

反応ノート

読み込み中…