4-Chloro-2-nitrobenzyl alcohol → (2-Amino-4-chlorophenyl)methanol

HRID 977187

反応式

HRID 977187 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[C:4]([N+:10]([O-])=O)[CH:3]=1.[H][H]>CO.[Pt]>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[C:4]([CH:3]=1)[NH2:10]

参加物

5

反応物 2

HCID 899564-Chloro-2-nitrobenzyl alcoholHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 4134900(2-Amino-4-chlorophenyl)methanol収率 100%

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 887Methanol溶媒

実験手順

To a solution of 4-chloro-2-nitro benzyl alcohol (25.00 g) in methanol (1 ltr) under nitrogen at room temperature, was added platinum on sulfided carbon (2.5 g, 10% by wt). The reaction mixture was shaken under 50 psi of hydrogen until the theoretical uptake of hydrogen had occurred. Filtration, then removal of the solvent in vacuo afforded the desired compound as a solid (21.00 g). δ (360 MHz, DMSO-d6) 4.35 (2H, d, J=4.95 Hz, CH2OH), 5.17 (1H, t, J=4.95 Hz, CH2OH), 6.77 (1H, dd, J=7.98 Hz, J=2.18 Hz, 4-H), 7.06 (1H, d, J=2.18 Hz, 6-H), 7.18 (1H, d, J=7.98 Hz, 3-H), 8.08 (1H, bs, NH2), 8.47 (1H, bs, NH).

後処理

  1. filtrationFiltration
  2. customremoval of the solvent in vacuo

出典と根拠

ORDレコード
ord-cf379bf4b10f44d29cf3b59deab7b83e
出典データセット
uspto-grants-1997_03
特許番号
US05614532

関連ノート

読み込み中…