Acetone → 5-[(6-Bromo-2-pyridyl)-methyl]-tetrahydrofuran-2-one
反応式
C[O:2][C:3](=[O:16])[CH2:4][CH2:5][C:6](=O)[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Br:14])[N:9]=1.[BH4-].[Na+].CC(C)=O>CO>[Br:14][C:10]1[N:9]=[C:8]([CH2:7][CH:6]2[O:16][C:3](=[O:2])[CH2:4][CH2:5]2)[CH:13]=[CH:12][CH:11]=1参加物
5
実験手順
A solution of 490 mg of 5-(6-bromo-2-pyridyl)-4-oxo-pentanoic acid methyl ester in 20 ml of methanol is mixed under ice cooling with 72 mg of sodium borohydride and stirred for 1 hour at 0°-3° C. Then, 2 ml of acetone is added, stirred for 1 more hour and the reaction mixture is evaporated to dryness. The residue is distributed between water and ethyl acetate, the organic phase is dried on sodium sulfate and concentrated by evaporation. 421 mg of 5-[(6-bromo-2-pyridyl)-methyl]-tetrahydrofuran-2-one is obtained as yellow oil.
後処理
- stirringstirred for 1 more hour
- customthe reaction mixture is evaporated to dryness
- customthe organic phase is dried on sodium sulfate
- concentrationconcentrated by evaporation
出典と根拠
- ORDレコード
- ord-a7a8db29ac714ebdbd6221408e500677
- 出典データセット
- uspto-grants-1997_03
- 特許番号
- US05614634
反応ノート
読み込み中…