Sodium Hydroxide → Lomerizine

HRID 977925

反応式

HRID 977925 の反応式
Cl.Cl.[CH3:3][O:4][C:5]1[C:32]([O:33][CH3:34])=[C:31]([O:35][CH3:36])[CH:30]=[CH:29][C:6]=1[CH2:7][N:8]1[CH2:13][CH2:12][N:11]([CH:14]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1.[OH-].[Na+]>>[CH3:3][O:4][C:5]1[C:32]([O:33][CH3:34])=[C:31]([O:35][CH3:36])[CH:30]=[CH:29][C:6]=1[CH2:7][N:8]1[CH2:9][CH2:10][N:11]([CH:14]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:12][CH2:13]1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 122125Lomerizine Hydrochloride

生成物 1

HCID 3949Lomerizine収率 64.2%

実験手順

The 1-(2,3,4-trimethoxybenzyl)-4-[bis(4-fluorophenyl)methyl]piperazine dihydrochloride obtained in Example 4 (20.0 g; 36.9 millimoles) was added to 100 ml of a 20% aqueous solution of sodium hydroxide. The resulting oily product was extracted with 100 ml of ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 11.1 g of 1-(2,3,4-trimethoxybenzyl)-4-[bis(4-fluorophenyl)methyl]piperazine as an oil.

後処理

  1. extractionThe resulting oily product was extracted with 100 ml of ethyl acetate
  2. dry with materialThe ethyl acetate layer was dried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-bd78c94178324c7cb3f7b4d19a91315c
出典データセット
uspto-grants-1987_05
特許番号
US04663325

関連ノート

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