3-(4-Hydroxyphenyl)propionic acid → 2-[3-(4-Hydroxyphenyl)propionylamino]acetic acid ethyl ester

HRID 978058ノート

反応式

HRID 978058 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([OH:12])=O)=[CH:4][CH:3]=1.Cl.[CH2:14]([O:16][C:17](=[O:20])[CH2:18][NH2:19])[CH3:15].C1N=CN(C(N2C=NC=C2)=O)C=1>CCN(CC)CC>[CH2:14]([O:16][C:17](=[O:20])[CH2:18][NH:19][C:10](=[O:12])[CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=1)[CH3:15]

参加物

5

反応物 3

HCID 103943-(4-Hydroxyphenyl)propionic acidHCID 682631,1'-CarbonyldiimidazoleHCID 2723640Glycine ethyl ester, hydrochloride

生成物 1

HCID 102641582-[3-(4-Hydroxyphenyl)propionylamino]acetic acid ethyl ester

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

3-(4-Hydroxyphenyl)propionic acid (2.49 g, 15 mmol) was reacted with glycine ethyl ester hydrochloride in the presence of CDI and Et3N as described in Example 56 Part A. After removal of the solvent the residue was dissolved in CHCl3 and washed with 1N HCl, saturated NaHCO3 solution and saturated NaCl solution. After drying (MgSO4) and removal of the solvent in vacuo crude title ester remained (2.44 g) as a viscous oil. NMR indicated this contained a major impurity but it was used without further purification.

後処理

  1. customAfter removal of the solvent the residue
  2. dissolutionwas dissolved in CHCl3
  3. washwashed with 1N HCl, saturated NaHCO3 solution and saturated NaCl solution
  4. customAfter drying
  5. custom(MgSO4) and removal of the solvent in vacuo crude title ester
  6. customwas used without further purification

出典と根拠

ORDレコード
ord-4dd7f704da564dc0bf4a8e71375752af
出典データセット
uspto-grants-1987_05
特許番号
US04663336

反応ノート

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