Ethyl bromoacetate → Ethyl (2-acetyl-3-hydroxyphenoxy)acetate

HRID 978104ノート

反応式

HRID 978104 の反応式
[CH3:1][C:2]([C:4]1[C:5]([OH:11])=[CH:6][CH:7]=[CH:8][C:9]=1[OH:10])=[O:3].Br[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:17]([O:16][C:14](=[O:15])[CH2:13][O:11][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([OH:10])[C:4]=1[C:2](=[O:3])[CH3:1])[CH3:18]

参加物

5

反応物 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 696872',6'-Dihydroxyacetophenone

生成物 1

HCID 4673143Ethyl (2-acetyl-3-hydroxyphenoxy)acetate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 2,6-dihydroxyacetophenone (40 g), ethyl bromoacetate (48 g) and potassium carbonate (58 g) in acetone (500 ml) was refluxed for 3 hours. The mixture was cooled and filtered. The solution was evaporated to dryness and the crude solid extracted with boiling hexane. Upon cooling, the title compound was obtained.

後処理

  1. temperaturewas refluxed for 3 hours
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. customThe solution was evaporated to dryness
  5. extractionthe crude solid extracted with boiling hexane
  6. temperatureUpon cooling

出典と根拠

ORDレコード
ord-5daafc56e4054350848aa44c9f5eec5d
出典データセット
uspto-grants-1987_05
特許番号
US04663347

反応ノート

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