Sodium Hydroxide → E-3-(4-hydroxy-3-methylbenzofuran-2-yl)propenoic acid

HRID 978119ノート

反応式

HRID 978119 の反応式
[OH:1][C:2]1[C:7]2[C:8]([CH3:18])=[C:9](/[CH:11]=[CH:12]/[C:13]([O:15]CC)=[O:14])[O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[OH:1][C:2]1[C:7]2[C:8]([CH3:18])=[C:9](/[CH:11]=[CH:12]/[C:13]([OH:15])=[O:14])[O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 13849545Ethyl (E)-3-(4-hydroxy-3-methylbenzofuran-2-yl)propenoate

生成物 1

HCID 13849550E-3-(4-hydroxy-3-methylbenzofuran-2-yl)propenoic acid収率 96.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of ethyl-E-3-(4-hydroxy-3-methylbenzofuran-2-yl)propenoate (225 mg, 0.9 mmoles) (From Example 159), 2N sodium hydroxide (4 ml) and methanol (15 ml) was stirred at room temperature for 36 hours. The mixture was concentrated, acidified with 20% citric acid solution and extracted with ether. The ether solution was dried with Na2SO4, filtered and concentrated to obtain 190 mg of the title compound, m.p. 246°-248° C. (dec.).

後処理

  1. concentrationThe mixture was concentrated
  2. extractionextracted with ether
  3. dry with materialThe ether solution was dried with Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-5d4c08c195b64b72b2ba6a5bd5e0b2db
出典データセット
uspto-grants-1987_05
特許番号
US04663347

反応ノート

読み込み中…