Hydrochloric Acid → 2-Amino-4-ethylbenzoic acid
反応式
[CH2:1]([C:3]1[CH:11]=[C:10]2[C:6]([C:7](=[O:13])C(=O)[NH:9]2)=[CH:5][CH:4]=1)[CH3:2].[OH-:14].[Na+].OO.Cl>>[CH2:1]([C:3]1[CH:11]=[C:10]([NH2:9])[C:6](=[CH:5][CH:4]=1)[C:7]([OH:13])=[O:14])[CH3:2]参加物
5
反応条件
- 温度
- 50 °C
実験手順
In a 500 ml flask, was placed 16.84 gm of 6-ethyl isatin which was covered with 216 ml of 1.5M sodium hydroxide solution. With stirring, the mixture was warmed to 50° C. Heating was discontinued and the solution was treated with a 30% solution of hydrogen peroxide (24 ml) which was added at such a rate to maintain the temperature at between 50° to 65° C. The mixture was left to slowly cool to room temperature and was then acidified to pH 4 with concentrated hydrochloric acid. The precipitated product was then collected by filtration: mp. 117°-120° C.; yield 8.93 gm.
後処理
- customIn a 500 ml flask, was placed
- temperatureHeating
- additionwas added at such a rate
- temperatureto maintain the temperature at between 50° to 65° C
- waitThe mixture was left
- temperatureto slowly cool to room temperature
- filtrationThe precipitated product was then collected by filtration
出典と根拠
- ORDレコード
- ord-36a80810a1724b698f3e85b59ff58f25
- 出典データセット
- uspto-grants-1987_05
- 特許番号
- US04665070
反応ノート
読み込み中…