Ethanol → 2-Methyl-4-hydroxy-anilino-methyl-2-imidazoline hydrochloride

HRID 978419

反応式

HRID 978419 の反応式
[NH2:1][C:2]1[C:3]([CH3:9])=[CH:4][C:5]([OH:8])=[CH:6][CH:7]=1.Cl.[Cl:11]C[C:13]1[NH:14][CH2:15][CH2:16][N:17]=1.[CH2:18](O)C>>[ClH:11].[CH3:9][C:3]1[CH:4]=[C:5]([OH:8])[CH:6]=[CH:7][C:2]=1[NH:1][C:13]1[N:14]([CH3:18])[CH2:15][CH2:16][N:17]=1

参加物

4

反応物 3

HCID 702EthanolHCID 178194-Amino-m-cresolHCID 27609282-(chloromethyl)-4,5-dihydro-1H-imidazole hydrochloride

生成物 1

HCID 704323792-Methyl-4-hydroxy-anilino-methyl-2-imidazoline hydrochloride

実験手順

Two moles 4-amino-m-cresol and 1 mole 2-chloromethyl-2-imidazoline hydrochloride are refluxed for 3 hours, within absolute ethanol. After cooling, the insoluble fraction is suction filtered and the ethanol solution is evaporated in vacuo. The evaporation residue is recrystallized from methanol:diethyl ether; M.p.=205°-207° C.

後処理

  1. temperatureAfter cooling
  2. filtrationfiltered
  3. customthe ethanol solution is evaporated in vacuo
  4. customThe evaporation residue is recrystallized from methanol

出典と根拠

ORDレコード
ord-04ce3127cf734f41816f9b8cfdd3b5c6
出典データセット
uspto-grants-1987_05
特許番号
US04665085

関連ノート

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