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Ethanol → 2-Methyl-4-hydroxy-anilino-methyl-2-imidazoline hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 4-Amino-m-cresol | HCID 17819 | — |
| 反応物 | 2-(chloromethyl)-4,5-dihydro-1H-imidazole hydrochloride | HCID 2760928 | — |
| 生成物 | 2-Methyl-4-hydroxy-anilino-methyl-2-imidazoline hydrochloride | HCID 70432379 | — |
反応手順
Two moles 4-amino-m-cresol and 1 mole 2-chloromethyl-2-imidazoline hydrochloride are refluxed for 3 hours, within absolute ethanol. After cooling, the insoluble fraction is suction filtered and the ethanol solution is evaporated in vacuo. The evaporation residue is recrystallized from methanol:diethyl ether; M.p.=205°-207° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04665085 |
| 出典データセット | uspto-grants-1987_05 |
| ORD ID | ord-04ce3127cf734f41816f9b8cfdd3b5c6 |
| 出典メモ | uspto-grants-1987_05 |