Sodium Hydroxide → 2-(4-Fluorophenyl)-2-(4-piperidyl)1,3-dioxolane

HRID 978436ノート

反応式

HRID 978436 の反応式
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[O:14][CH2:13][CH2:12][O:11]2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>>[F:21][C:18]1[CH:19]=[CH:20][C:15]([C:10]2([CH:7]3[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]3)[O:14][CH2:13][CH2:12][O:11]2)=[CH:16][CH:17]=1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 191009161-Acetyl-4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]piperidine

生成物 1

HCID 132790992-(4-Fluorophenyl)-2-(4-piperidyl)1,3-dioxolane収率 82%

実験手順

A mixture of 5 parts of 1-acetyl-4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]piperidine and 100 parts of a sodium hydroxide solution 10% was stirred and refluxed overnight. The reaction mixture was cooled and the product was extracted with trichloromethane. The extract was dried, filtered and evaporated. The solid residue was stirred in 2,2'-oxybispropane. The product was filtered off and dried in vacuo at 40° C., yielding 3.5 parts (82%) of 4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]piperidine (2).

後処理

  1. temperaturerefluxed overnight
  2. temperatureThe reaction mixture was cooled
  3. extractionthe product was extracted with trichloromethane
  4. customThe extract was dried
  5. filtrationfiltered
  6. customevaporated
  7. stirringThe solid residue was stirred in 2,2'-oxybispropane
  8. filtrationThe product was filtered off
  9. customdried in vacuo at 40° C.

出典と根拠

ORDレコード
ord-3121c6604aeb4d80b453b9e1b0855870
出典データセット
uspto-grants-1987_05
特許番号
US04665075

反応ノート

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