Ethylamine → HCID 13137236、化合物
反応式
[CH2:1]([NH2:3])[CH3:2].[CH2:4]([CH:9]1[C:13](O)([CH3:14])[CH:12]=[CH:11][C:10]1=[O:16])[CH2:5][CH2:6][CH2:7][CH3:8]>O1CCCC1>[CH2:4]([C:9]1[C:10](=[O:16])[CH2:11][CH:12]([NH:3][CH2:1][CH3:2])[C:13]=1[CH3:14])[CH2:5][CH2:6][CH2:7][CH3:8]参加物
4
実験手順
Into a four-necked flask equipped with a stirrer and a thermometer, a 30% aqueous solution of monoethylamine (70 g) and tetrahydrofuran (18 g) were charged, and then 2-n-pentyl-3-hydroxy-3-methyl-4-cyclopentenone (18.2 g) was dropwise added thereto at a temperature of 10° to 20° C. for 30 minutes. At the same temperature, the reaction mixture was kept for 2 hours. After completion of the reaction, the mixture was extracted with toluene, and the organic layer was washed with water. From the organic layer, toluene was evaporated off to give 2-n-pentyl-3-methyl-4-ethylamino-2-cyclopentenone (20.3 g). Yeild, 97%. The product was purified by alumina chromatography using toluene-ethyl acetate (10:1 by volume). nD20 1.4864.