Folic Acid → Tetrahydrofolic acid

HRID 978627

反応式

HRID 978627 の反応式
[C:1]([OH:32])(=[O:31])[CH2:2][CH2:3][C@H:4]([NH:8][C:9]([C:11]1[CH:30]=[CH:29][C:14]([NH:15][CH2:16][C:17]2[N:28]=[C:27]3[C:20]([N:21]=[C:22]([NH:24][C:25]3=[O:26])[NH2:23])=[N:19][CH:18]=2)=[CH:13][CH:12]=1)=[O:10])[C:5]([OH:7])=[O:6]>O.[Pt]=O>[C:1]([OH:32])(=[O:31])[CH2:2][CH2:3][C@H:4]([NH:8][C:9]([C:11]1[CH:12]=[CH:13][C:14]([NH:15][CH2:16][CH:17]2[NH:28][C:27]3[C:25](=[O:26])[NH:24][C:22]([NH2:23])=[N:21][C:20]=3[NH:19][CH2:18]2)=[CH:29][CH:30]=1)=[O:10])[C:5]([OH:7])=[O:6]

参加物

4

反応物 1

HCID 135398658Folic Acid

生成物 1

HCID 135444742Tetrahydrofolic acid収率 74.9%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 962Water溶媒

実験手順

Then, a suspension of 0.0687 g of platinum oxide (containing the noble metal in an amount of 1.5% by weight based on the folic acid) in 50 ml of distilled water was added to the flask, and hydrogenation was carried out in the same manner as described in Example 1 to obtain 2.973 g (74.9% yield) of tetrahydrofolic acid.

後処理

  1. additioncontaining the noble metal in an amount of 1.5% by weight
  2. additionwas added to the flask, and hydrogenation

出典と根拠

ORDレコード
ord-357e9547bcf64640be111d58f575916c
出典データセット
uspto-grants-1987_05
特許番号
US04665176

関連ノート

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