4-Toluenesulfonyl chloride → 11-Phenylundecanol tosylate

HRID 978677ノート

反応式

HRID 978677 の反応式
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[C:12]1([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][OH:29])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>N1C=CC=CC=1>[S:7]([O:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)([C:4]1[CH:5]=[CH:6][C:1]([CH3:11])=[CH:2][CH:3]=1)(=[O:9])=[O:8]

参加物

4

反応物 2

HCID 73974-Toluenesulfonyl chlorideHCID 11651716Benzeneundecanol

生成物 1

HCID 5393925311-Phenylundecanol tosylate

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

4-Toluenesulphonyl chloride (2.6 g) was added in portions to a stirred solution of the product of step (a) (2.9 g) in pyridine (10 ml) at 0° C. The solution was stirred for 16 hours at 0°-5° C. then poured onto ice-hydrochloric acid and extracted with ether. The extract was washed with sodium bicarbonate and sodium chloride solutions, dried and evaporated. The residue was chromatographed on silica gel eluting with 1:1 dichloromethane:hexane to give the title compound as a colourless oil.

後処理

  1. additionthen poured onto ice-hydrochloric acid
  2. extractionextracted with ether
  3. washThe extract was washed with sodium bicarbonate and sodium chloride solutions
  4. customdried
  5. customevaporated
  6. customThe residue was chromatographed on silica gel eluting with 1:1 dichloromethane

出典と根拠

ORDレコード
ord-c6796cba41954d6eb4b6efc77229340b
出典データセット
uspto-grants-1987_05
特許番号
US04665189

反応ノート

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