Toluene → Gemfibrozil

HRID 978803

反応式

HRID 978803 の反応式
Cl[CH2:2][CH2:3][CH2:4][C:5]([CH3:14])([CH3:13])[C:6]([O:8]CC(C)C)=[O:7].[CH3:15][C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=1[O-:23].[Na+].C1(C)C=CC=CC=1>CS(C)=O>[CH3:15][C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=1[O:23][CH2:2][CH2:3][CH2:4][C:5]([CH3:14])([CH3:13])[C:6]([OH:8])=[O:7]

参加物

5

反応物 3

HCID 1140Toluene2 回HCID 139137102-Methylpropyl 5-chloro-2,2-dimethylpentanoateHCID 23672785Sodium 2,5-dimethylphenolate

生成物 1

HCID 3463Gemfibrozil収率 80%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒2 回

実験手順

subsequently reacting said 2-methylpropyl 5-chloro-2,2-dimethylpentanoate with sodium 2,5-dimethylphenolate under reflux in a solvent comprising a mixture of from 10 parts (V/V) toluene/1 part (V/V) dimethylsulfoxide to 5 parts (V/V) toluene/1 part (V/V) dimethylsulfoxide, hydrolyzing the resulting ester, and thereafter acidifying the mixture and isolating 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid;

後処理

  1. temperatureunder reflux in a solvent comprising

出典と根拠

ORDレコード
ord-236b92105dd24bb1a6f646a20ccc4c94
出典データセット
uspto-grants-1987_05
特許番号
US04665226

関連ノート

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