Ethanol → HCID 20159085、化合物

HRID 978820ノート

反応式

HRID 978820 の反応式
C(O)C.[N+:4]([C:7]1[CH:12]=[CH:11][C:10]([N:13]=[C:14]=[O:15])=[CH:9][CH:8]=1)([O-:6])=[O:5].[CH2:16]([NH:19][C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=1)[CH2:17][CH3:18]>C(#N)C>[N+:4]([C:7]1[CH:8]=[CH:9][C:10]([NH:13][C:14]([N:19]([C:20]2[CH:21]=[CH:22][C:23]([Cl:26])=[CH:24][CH:25]=2)[CH2:16][CH2:17][CH3:18])=[O:15])=[CH:11][CH:12]=1)([O-:6])=[O:5]

参加物

5

反応物 3

HCID 702EthanolHCID 66012Benzene, 1-isocyanato-4-nitro-HCID 125129094-chloro-N-propylaniline

生成物 1

HCID 20159085HCID 20159085、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

1.09 g of 2-chlorobenzoylisocyanate was added to a solution of 2.00 g of N-(4-aminophenyl)-N'-(4-chlorophenyl)-N'-propylurea in 50 ml of acetonitrile while stirring at room temperature. After stirring for 1.5 hours at room temperature the formed precipate was sucked off, washed with diethyl ether, and dried. According to PMR the product had the desired structure; the product melted at 170° C. The starting aniline was obtained from the corresponding nitro compound by reduction with hydrogen under the influence of Raney nickel as a catalyst; in this reaction ethanol was used as a solvent. N-(4-nitrophenyl)-N'-(4-chlorophenyl)-N'-propylurea was prepared by a coupling of p-nitrophenylisocyanate with N-propyl-4-chloroaniline in acetonitrile as a solvent. In a corresponding manner, in which, if desired, instead of acetonitrile diethyl ether was used as a solvent for the first-mentioned reaction, the following compounds were prepared; the compound numbers correspond again with the number given before in the specification:

後処理

  1. customwas used as a solvent for the first-mentioned reaction
  2. customthe following compounds were prepared

出典と根拠

ORDレコード
ord-8f4c9fd5af324d23b548b761c3f75095
出典データセット
uspto-grants-1987_05
特許番号
US04665235

反応ノート

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