N-Cbz-2-amino-2-methyl-1-[di-(t-butyl)methoxy]propane → 2-Amino-2-methyl-1-[di-(t-butyl)methoxy]propane

HRID 979014ノート

反応式

HRID 979014 の反応式
C([NH:11][C:12]([CH3:25])([CH3:24])[CH2:13][O:14][CH:15]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:16]([CH3:19])([CH3:18])[CH3:17])(OCC1C=CC=CC=1)=O>CO.[Pd]>[NH2:11][C:12]([CH3:25])([CH3:24])[CH2:13][O:14][CH:15]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:16]([CH3:18])([CH3:17])[CH3:19]

参加物

4

反応物 1

HCID 20201229N-Cbz-2-amino-2-methyl-1-[di-(t-butyl)methoxy]propane

生成物 1

HCID 139307012-Amino-2-methyl-1-[di-(t-butyl)methoxy]propane

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

N-Cbz-2-amino-2-methyl-1-[di-(t-butyl)methoxy]propane is dissolved in CH3OH and hydrogenated over 5% Pd/C in a Paar hydrogenation apparatus. When the reaction is complete the mixture is filtered through Celite and concentrated to yield 2-amino-2-methyl-1-[di-(t-butyl)methoxy]propane.

後処理

  1. filtrationis filtered through Celite
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-6393eb9002b64188b58e4975176cbf61
出典データセット
uspto-grants-1987_05
特許番号
US04666729

反応ノート

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