Sodium Carbonate → Sodium 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate

HRID 979138ノート

反応式

HRID 979138 の反応式
[CH3:1][CH:2]([CH3:22])[CH2:3][O:4][C:5]1[CH:21]=[CH:20][CH:19]=[CH:18][C:6]=1[NH:7][C:8]1[NH:9][C:10](=[O:17])[C:11]([C:14]([OH:16])=[O:15])=[CH:12][N:13]=1.C(=O)([O-])[O-].[Na+:27].[Na+]>C(O)C.O>[CH3:1][CH:2]([CH3:22])[CH2:3][O:4][C:5]1[CH:21]=[CH:20][CH:19]=[CH:18][C:6]=1[NH:7][C:8]1[NH:9][C:10](=[O:17])[C:11]([C:14]([O-:16])=[O:15])=[CH:12][N:13]=1.[Na+:27]

参加物

5

反応物 2

HCID 10340Sodium CarbonateHCID 9817898Mar 99

生成物 1

HCID 23692303Sodium 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate収率 57.8%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A mixture of 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylic acid (20 g) and sodium carbonate (7.0 g) in ethanol (100 ml) and water (100 ml) is heated until the solution is completed. After allowing to stand the solution overnight, the precipitate is collected by filtration, washed with water and dried to give sodium 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate (12.4 g). M.p. 231°-233° C.

後処理

  1. temperatureis heated until the solution
  2. customthe solution overnight
  3. filtrationthe precipitate is collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-245f2c7448ab4c7e88f50af9908cd9d3
出典データセット
uspto-grants-1987_05
特許番号
US04666915

反応ノート

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