Chlorosulfonic acid → HCID 20201784、化合物
反応式
[C:1]([C:4]1[O:5][C:6]2[C:12]([O:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=3)=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[CH3:2].[Cl:24][S:25](O)(=[O:27])=[O:26]>>[C:1]([C:4]1[O:5][C:6]2[C:12]([O:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=3)=[CH:11][CH:10]=[C:9]([S:25]([Cl:24])(=[O:27])=[O:26])[C:7]=2[CH:8]=1)(=[O:3])[CH3:2]参加物
3
実験手順
2-Acetyl-7-p-nitrobenzyloxybenzofuran (3 g) was added to chlorosulfonic acid at -15° C. for 30 minutes. After the reaction mixture was stirred at -10° to -5° C. for 1 hour, the resultant was gradually added dropwise to ice-water. The solution was extracted with ethyl acetate, washed with water and dried, ethyl acetate being distilled away under reduced pressure to give 2.7 g of crude 2-acetyl-4-chlorosulfonyl-7-p-nitrobenzyloxybenzofuran.
後処理
- extractionThe solution was extracted with ethyl acetate
- washwashed with water
- customdried
- distillationethyl acetate being distilled away under reduced pressure