Water → chloromaleic acid N-[2-(2-methoxyphenyl)-ethyl]-imide

HRID 979228

反応式

HRID 979228 の反応式
[Cl:1][C:2]1[C:3]([O:5][C:6](=[O:8])[CH:7]=1)=[O:4].[CH3:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][NH2:19].O>C(O)(=O)C>[CH3:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][N:19]=[C:3]([OH:4])/[C:2](/[Cl:1])=[CH:7]\[C:6]([OH:5])=[O:8]

参加物

5

反応物 3

HCID 962WaterHCID 66772Chloromaleic anhydrideHCID 748962-Methoxyphenethylamine

生成物 1

HCID 178489456chloromaleic acid N-[2-(2-methoxyphenyl)-ethyl]-imide収率 78%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

13.25 g (0.1 mol) of chloromaleic anhydride and 15.2 g (0.1 mol) of 2-(2-methoxyphenyl)-ethylamine are heated to the boiling point in 100 ml of glacial acetic acid for 4 hours. 100 ml of water are then added and the oil which has precipitated is extracted with methylene chloride. The methylene chloride phase is separated off, washed with water, dried and evaporated. The oil which remains crystallizes. 20.8 g (78% of theory) of chloromaleic acid N-[2-(2-methoxyphenyl)-ethyl]-imide are obtained.

後処理

  1. customthe oil which has precipitated
  2. extractionis extracted with methylene chloride
  3. customThe methylene chloride phase is separated off
  4. washwashed with water
  5. customdried
  6. customevaporated
  7. customThe oil which remains crystallizes

出典と根拠

ORDレコード
ord-33887f723c6e4b00a2adcfa2a364aa5b
出典データセット
uspto-grants-1987_05
特許番号
US04666935

関連ノート

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