Potassium Hydroxide → 3-[(Dibenzylamino)oxy]propanoic acid

HRID 979261ノート

反応式

HRID 979261 の反応式
[CH2:1]([N:8]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[O:9][CH2:10][CH2:11][C:12]([O:14]C)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+]>O1CCCC1.O>[CH2:16]([N:8]([CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[O:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 21621270HCID 21621270、化合物

生成物 1

HCID 235038743-[(Dibenzylamino)oxy]propanoic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 22.4 g of methyl 3-[N,N-dibenzylaminoxy]propanoate and 4.50 g of potassium hydroxide in 200 ml of tetrahydrofuran and 200 ml of water is heated under reflux for 12 hours under N2. The mixture is concentrated under reduced pressure and the residue is partitioned between water and ether. The combined aqueous extracts are acidified with hydrochloric acid and then extracted with methylene chloride. The combined organic extracts are dried (MgSO4) and evaporated under reduced pressure to afford the title compound as a pale yellow oil.

後処理

  1. temperatureunder reflux for 12 hours under N2
  2. concentrationThe mixture is concentrated under reduced pressure
  3. customthe residue is partitioned between water and ether
  4. extractionextracted with methylene chloride
  5. dry with materialThe combined organic extracts are dried (MgSO4)
  6. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-c4040b9dd1044af0b6ee41a257c75a4d
出典データセット
uspto-grants-1987_05
特許番号
US04666962

反応ノート

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