Water → Phenothiazone

HRID 979289

反応式

HRID 979289 の反応式
[CH:1]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[S:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[OH2:15]>CC(O)=O.CC(C)=O>[CH:11]1[C:12]2[C:7]([S:6][C:5]3[C:14]([N:13]=2)=[CH:1][CH:2]=[CH:3][CH:4]=3)=[CH:8][C:9](=[O:15])[CH:10]=1

参加物

5

反応物 2

HCID 962WaterHCID 7108Phenothiazine

生成物 1

HCID 68485Phenothiazone

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 180Acetone溶媒

実験手順

To a stirring solution of 1.1 kg of ceric ammonium nitrate in 12.5 liters of H2O and 1.25 liters of HOAc at 10° C. was added dropwise a solution of 100 g of phenothiazine in 500 ml acetone over a period of 20 minutes. The resulting mixture was stirred for another 20 minutes and the product 3H-phenothiazin-3-one was then filtered off. The filtered 3H-phenothiazin-3-one was washed with water thoroughly and dried to give 92 g of crude 3H-phenothiazin-3-one. The crude 3H-phenothiazin-3-one was extracted with minimum volume of CH2Cl2. Upon dilution of the CH2Cl2 solution with 10 times the volume of cyclohexane, a precipitate was formed which was filtered and dried to afford 35 g of 3H-phenothiazin-3-one.

後処理

  1. filtrationthe product 3H-phenothiazin-3-one was then filtered off
  2. washThe filtered 3H-phenothiazin-3-one was washed with water thoroughly
  3. customdried

出典と根拠

ORDレコード
ord-068510e2bf1a473db170381354cbacf4
出典データセット
uspto-grants-1987_05
特許番号
US04667032

関連ノート

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