Dimethylformamide → 3-Chloro-1-methyl-1,2-dihydroquinoxalin-2-one

HRID 979463

反応式

HRID 979463 の反応式
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4](=O)[C:3]1=[O:13].CN(C=O)C.S(Cl)([Cl:21])=O>C1(C)C=CC=CC=1>[Cl:21][C:4]1[C:3](=[O:13])[N:2]([CH3:1])[C:11]2[C:6]([N:5]=1)=[CH:7][CH:8]=[CH:9][CH:10]=2

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 6006271-Methyl-1,4-dihydro-2,3-quinoxalinedione

生成物 1

HCID 14710883-Chloro-1-methyl-1,2-dihydroquinoxalin-2-one

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 56.1 g. (0.32 m.) of 1,4-dihydro-1-methylquinoxalin-2,3-dione, 10 ml. of DMF, 50 ml. (0.67 m.) of thionyl chloride and 1 l. of toluene was refluxed for 1 hour, cooled, and stripped, finally under high vacuum to a crude dark solid, m.p. 124°-130° C. of sufficient purity to use in the next step.

後処理

  1. additionA mixture of 56.1 g
  2. temperaturecooled

出典と根拠

ORDレコード
ord-09d9ee2c8d7d469888f7ac08171b223c
出典データセット
uspto-grants-1987_05
特許番号
US04668678

関連ノート

読み込み中…