Acetonitrile → HCID 4914114、化合物

HRID 979469ノート

反応式

HRID 979469 の反応式
[NH2:1][C:2]1[C:11]([F:12])=[C:10](F)[C:9]([F:14])=[C:8]2[C:3]=1[C:4](=[O:21])[C:5]([C:18]([OH:20])=[O:19])=[CH:6][N:7]2[CH:15]1[CH2:17][CH2:16]1.[CH2:22]([N:24]([CH2:27]C)[CH2:25][CH3:26])[CH3:23].C(#[N:31])C>>[NH2:1][C:2]1[C:11]([F:12])=[C:10]([N:31]2[CH2:26][CH2:25][N:24]([CH3:27])[CH2:22][CH2:23]2)[C:9]([F:14])=[C:8]2[C:3]=1[C:4](=[O:21])[C:5]([C:18]([OH:20])=[O:19])=[CH:6][N:7]2[CH:15]1[CH2:16][CH2:17]1

参加物

4

反応物 3

HCID 6342AcetonitrileHCID 8471TriethylamineHCID 139109475-Amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

生成物 1

HCID 4914114HCID 4914114、化合物

実験手順

A suspension of 1.0 g (3.35 mmole) of 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 1.36 g (13.35 mmole) of triethylamine and 60 ml of acetonitrile is refluxed for eight hours and stirred at room temperature for 16 hours. The precipitate is removed by filteration, washed with acetonitrile, and dried in vacuo at 45° C. to give 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinoline-carboxylic acid, mp 247°-248° C.

後処理

  1. temperatureis refluxed for eight hours
  2. customThe precipitate is removed by filteration
  3. washwashed with acetonitrile
  4. customdried in vacuo at 45° C.

出典と根拠

ORDレコード
ord-9d5bb92d369b45b587e832d4c6a0f785
出典データセット
uspto-grants-1987_05
特許番号
US04668680

反応ノート

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