Water → alpha-Hydroxy[2-(beta,beta,beta-trichloroethoxycarbonyl)aminothiazol-4-yl]acetonitrile

To a mixture of 1.0 g. of 2-(β,β,β-trichloroethoxycarbonyl)amino-4-formylthiazole, 0.87 g. of KH2PO4, 6 ml. of water and 4 ml. of dimethylformamide is added 0.33 g. of KCN at room temperature and the mixture is stirred for 30 minutes. The reaction mixture is extracted with ethyl acetate and ethyl acetate layer is washed with water and dried. Evaporation of ethyl acetate gives α-hydroxy[2-(β,β,β-trichloroethoxycarbonyl)aminothiazol-4-yl]acetonitrile 1.127 g.

1. additionTo a mixture of 1.0 g
2. extractionThe reaction mixture is extracted with ethyl acetate and ethyl acetate layer
3. washis washed with water
4. customdried
5. customEvaporation of ethyl acetate

ORDレコード

ord-a8f1d3d0b4674e15bd04d7828e1f1b3c

出典データセット

uspto-grants-1987_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04668783