Sodium Acetate → 2-Methyl-2,3-dihydro-1-benzofuran-7-sulfonamide
反応式
Br[C:2]1[CH:11]=[C:10]([S:12](=[O:15])(=[O:14])[NH2:13])[C:5]2[O:6][CH:7]([CH3:9])[CH2:8][C:4]=2[CH:3]=1.C([O-])(=O)C.[Na+]>[Pd].CO>[CH3:9][CH:7]1[O:6][C:5]2[C:10]([S:12](=[O:15])(=[O:14])[NH2:13])=[CH:11][CH:2]=[CH:3][C:4]=2[CH2:8]1参加物
5
実験手順
72.5 g (0.25 mole) of 5-bromo-2,3-dihydro-2-methyl-7-sulfamoylbenzo[b]furan are hydrogenated in the presence of 22.4 g (0.25 mole) of sodium acetate and 7.5 g of 5% palladium on carbon catalyst in 750 ml of methanol. The catalyst is removed, the solvent evaporated, and the residue crystallised from a mixture of water/ethanol, affording 42.3 g (79% of theory) of 2,3-dihydro-2-methyl-7-sulfamoylbenzo[b]furan with a melting point of 174°-177° C.
後処理
- customThe catalyst is removed
- customthe solvent evaporated
- customthe residue crystallised from a mixture of water/ethanol
出典と根拠
- ORDレコード
- ord-4699cda7af36402b85fcc904772761a7
- 出典データセット
- uspto-grants-1987_01
- 特許番号
- US04634465
反応ノート
読み込み中…