4-Fluorophenyl isocyanate → HCID 20223045、化合物

HRID 979780

反応式

HRID 979780 の反応式
[NH:1]1[C:8](=[O:9])[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[S:3].[F:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]=[C:18]=[O:19])=[CH:13][CH:12]=1>N1C=CC=CC=1>[F:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18]([C:7]2[C:8](=[O:9])[NH:1][C:2](=[S:3])[NH:4][C:5]=2[OH:6])=[O:19])=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 709554-Fluorophenyl isocyanateHCID 2723628Thiobarbituric acid

生成物 1

HCID 20223045HCID 20223045、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
90 °C

実験手順

2-thiobarbituric acid (14.4 g) was suspended in pyridine and 4-fluorophenyl isocyanate (13.7 g) was added thereto. The reaction mixture was maintained at 90° C. for one hour, and thereafter left overnight at room temperature. The solids formed were collected, washed with pyridine, re-suspended in ethanol, and again collected and dried. A pale pink powder product was thereby obtained, mp >250° C. (dec.), NMR (DMSO) 7.0-7.7δ (multiplet, integral 4); 10.7-11.4δ (overlapping broad singlets, combined integral 4). MS, M/e 281 (Calc., 281).

後処理

  1. customThe solids formed
  2. customwere collected
  3. washwashed with pyridine
  4. customagain collected
  5. customdried
  6. customA pale pink powder product was thereby obtained

出典と根拠

ORDレコード
ord-8411a693a2244562bb1b98915c09dac2
出典データセット
uspto-grants-1987_01
特許番号
US04634707

関連ノート

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