Sodium borohydride → HCID 67933784、化合物
反応式
[C:1]([CH2:3][O:4][C:5]1[C:14]([O:15][CH3:16])=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][CH:9]=[CH:10]2)#[N:2].[BH4-].[Na+]>C(O)C>[C:1]([CH2:3][O:4][C:5]1[C:14]([O:15][CH3:16])=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][CH2:9][CH2:10]2)#[N:2]参加物
4
実験手順
The product from Example 1 (10.5 g) was refluxed for 2.5 hours in ethanol (200 ml) containing sodium borohydride (6 g). The reaction was cooled to room temperature and evaporated to dryness. Aqueous hydrochloric acid (50 ml) was carefully added followed by extraction with dichloromethane. The organic layer was separated, dried and evaporated affording 8.4 g. of the desired product (79% yield); m.p. 50°-1° C.
後処理
- customevaporated to dryness
- additionAqueous hydrochloric acid (50 ml) was carefully added
- extractionfollowed by extraction with dichloromethane
- customThe organic layer was separated
- customdried
- customevaporated
- customaffording 8.4 g
出典と根拠
- ORDレコード
- ord-b65d9d8e99f146ffb1dbc72a2cb311ce
- 出典データセット
- uspto-grants-1987_01
- 特許番号
- US04634705
反応ノート
読み込み中…