Sodium Hydroxide → 4-Ethoxy-3,5-dimethyl-2-pyridylmethanol

HRID 979862ノート

反応式

HRID 979862 の反応式
C([O:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH2:14][CH3:15])[C:9]([CH3:16])=[CH:8][N:7]=1)(=O)C.[OH-].[Na+]>C(O)C>[CH2:14]([O:13][C:10]1[C:9]([CH3:16])=[CH:8][N:7]=[C:6]([CH2:5][OH:4])[C:11]=1[CH3:12])[CH3:15]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 22151469(4-Ethoxy-3,5-dimethyl-2-pyridyl)methyl acetate

生成物 1

HCID 199637424-Ethoxy-3,5-dimethyl-2-pyridylmethanol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

32.9 g of (4-ethoxy-3,5-dimethyl-2-pyridyl)methyl acetate were dissolved in 190 ml of ethanol. 95 ml of 3N sodium hydroxide solution were then added dropwise thereto at 0° and the mixture was stirred at room temperature for a further 3 hours. The ethanol was subsequently removed in vacuo and the residual aqueous solution was extracted three times with 200 ml of methylene chloride. The organic extracts were dried over sodium sulfate and evaporated in vacuo. The residue crystallized from petroleum ether and there was obtained 4-ethoxy-3,5-dimethyl-2-pyridylmethanol of melting point 58°-59°.

後処理

  1. customThe ethanol was subsequently removed in vacuo
  2. extractionthe residual aqueous solution was extracted three times with 200 ml of methylene chloride
  3. dry with materialThe organic extracts were dried over sodium sulfate
  4. customevaporated in vacuo
  5. customThe residue crystallized from petroleum ether

出典と根拠

ORDレコード
ord-56996fc754c547429746aec39ca9f110
出典データセット
uspto-grants-1987_01
特許番号
US04634710

反応ノート

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