Sodium Hydroxide → (4-Methoxy-5-methylpyridin-2-yl)methanol
反応式
C([O:4][CH2:5][C:6]1[CH:11]=[C:10]([O:12][CH3:13])[C:9]([CH3:14])=[CH:8][N:7]=1)(=O)C.[OH-].[Na+]>C(O)C>[CH3:13][O:12][C:10]1[C:9]([CH3:14])=[CH:8][N:7]=[C:6]([CH2:5][OH:4])[CH:11]=1参加物
4
実験手順
47.8 g of (4-methoxy-5-methyl-2-pyridyl)methyl acetate were dissolved in 330 ml of ethanol. 165 ml of 3N sodium hydroxide solution were then added dropwise thereto at 0° and the mixture was stirred at room temperature for a further 3 hours. The ethanol was subsequently removed in vacuo, whereupon the residual aqueous solution was extracted three times with 250 ml of methylene chloride. The organic extracts were dried over sodium sulfate and evaporated in vacuo. The residue crystallizes from petroleum ether and there was obtained 4-methoxy-5-methyl-2-pyridylmethanol of melting point 101°-103°.
後処理
- customThe ethanol was subsequently removed in vacuo, whereupon the residual aqueous solution
- extractionwas extracted three times with 250 ml of methylene chloride
- dry with materialThe organic extracts were dried over sodium sulfate
- customevaporated in vacuo
- customThe residue crystallizes from petroleum ether
出典と根拠
- ORDレコード
- ord-33a7517123d945b9887ac612b6e7af31
- 出典データセット
- uspto-grants-1987_01
- 特許番号
- US04634710
反応ノート
読み込み中…