Diethyl Ether → HCID 20159920、化合物

HRID 980009ノート

反応式

HRID 980009 の反応式
C(OC([NH:8][CH2:9][CH:10]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:11][CH2:12][NH:13][S:14]([C:17]1[C:18]2[CH:19]=[CH:20][N:21]=[CH:22][C:23]=2[CH:24]=[CH:25][CH:26]=1)(=[O:16])=[O:15])=O)(C)(C)C.C(OCC)C>FC(F)(F)C(O)=O>[NH2:8][CH2:9][CH:10]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:11][CH2:12][NH:13][S:14]([C:17]1[C:18]2[CH:19]=[CH:20][N:21]=[CH:22][C:23]=2[CH:24]=[CH:25][CH:26]=1)(=[O:16])=[O:15]

参加物

4

反応物 2

HCID 3283Diethyl EtherHCID 20159947HCID 20159947、化合物

生成物 1

HCID 20159920HCID 20159920、化合物収率 97%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

In 30 ml of trifluoroacetic acid was dissolved 6.0 g of N-(4-t-butoxycarbonylamino-3-phenylbutyl)-5-isoquinolinesulfonamide, and left at a temperature of 20° C.~25° C. for 30 minutes. The mixrure was condensed under reduced pressure. To the reaction solution was added ethyl ether, and the crystals precipitated were separated by filtration. The crystals thus obtained were washed with ethylether to give 4.54 g of N-(4-amino-3-phenylbutyl)-5-isoquinolinesulfonamide in a yield of 97%.

後処理

  1. customcondensed under reduced pressure
  2. customthe crystals precipitated
  3. customwere separated by filtration
  4. customThe crystals thus obtained
  5. washwere washed with ethylether

出典と根拠

ORDレコード
ord-a15db979ebc54b889a356f3f03824796
出典データセット
uspto-grants-1987_01
特許番号
US04634770

反応ノート

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