2-Ethyl-7-(phenylmethyl)-2,7-diazaspiro[4.4]nonane dihydrochloride → 2-Ethyl-2,7-diazaspiro[4.4]nonane dihydrochloride
反応式
[ClH:1].Cl.[CH2:3]([N:10]1[CH2:14][CH2:13][C:12]2([CH2:18][CH2:17][N:16](CC)[CH2:15]2)[CH2:11]1)[C:4]1C=CC=CC=1>CO.[Pd]>[ClH:1].[ClH:1].[CH2:3]([N:10]1[CH2:14][CH2:13][C:12]2([CH2:18][CH2:17][NH:16][CH2:15]2)[CH2:11]1)[CH3:4]参加物
4
実験手順
A solution of 9.50 g (0.030 mole) 2-benzyl-7-ethyl-2,7-diazaspiro[4.4]nonane dihydrochloride in 100 ml methanol was hydrogenated with 1.0 g 20% palladium on carbon catalyst at 4.5×105Pa for 22 hours. After filtration, the solution was concentrated to a syrup and crystallized from acetonitrile to afford 6.66 g of the title compound, mp 168°-172° C.
後処理
- filtrationAfter filtration
- concentrationthe solution was concentrated to a syrup
- customcrystallized from acetonitrile
出典と根拠
- ORDレコード
- ord-d5a47719e7614c70b9405ee93aa3df97
- 出典データセット
- uspto-grants-1987_01
- 特許番号
- US04638067
反応ノート
読み込み中…