2,4-Dichlorobenzaldehyde → HCID 2872053、化合物

HRID 980844ノート

反応式

HRID 980844 の反応式
[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:11](O)(=[S:15])[CH:12](C)O.[CH:17]([O-:19])=O.[NH4+:20]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[CH:4]1[NH:20][C:17](=[O:19])[CH:11]([CH3:12])[S:15]1

参加物

5

反応物 3

HCID 134042,4-DichlorobenzaldehydeHCID 2723923Ammonium formateHCID 178473673HCID 178473673、化合物

生成物 1

HCID 2872053HCID 2872053、化合物収率 85.3%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

In a 500 ml 3-necked flask equipped with a Dean & Stark trap and reflux condenser, 30 g (0.17 mole) 2,4-dichlorobenzaldehyde, 18.2 g (0.17 mole) 95% thiolactic acid and 10.8 g (0.17 mole) ammonium formate in 150 ml toluene were placed. The reaction mixture was heated to reflux for several hours; 17 ml water collected. The mixture was at first clear in color and then turned yellow. The reaction mixture was allowed to sit overnight during which yellow solids precipitated. The mixture was filtered. The solids were washed with ether and then air dried to give 38 g of the above-identified product as a white solid.

後処理

  1. customIn a 500 ml 3-necked flask equipped with a Dean & Stark trap
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture was heated
  4. temperatureto reflux for several hours
  5. custom17 ml water collected
  6. customprecipitated
  7. filtrationThe mixture was filtered
  8. washThe solids were washed with ether
  9. customair dried

出典と根拠

ORDレコード
ord-4a90b5d585b84a69abc30eb38845b60c
出典データセット
uspto-grants-1987_01
特許番号
US04639460

反応ノート

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