HCID 67831590、化合物 → 2,4-Azetidinedicarboxylic acid, mono(1,1-dimethylethyl) ester, cis-

HRID 981029ノート

反応式

HRID 981029 の反応式
[C:1]([O:5][C:6]([C@H:8]1[N:11](CC2C=CC=CC=2)[C@@H:10]([C:19]([O:21]CC2C=CC=CC=2)=[O:20])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>[Pd].CO>[C:1]([O:5][C:6]([C@H:8]1[CH2:9][C@@H:10]([C:19]([OH:21])=[O:20])[NH:11]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 2

HCID 67831590HCID 67831590、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 146544092,4-Azetidinedicarboxylic acid, mono(1,1-dimethylethyl) ester, cis-収率 94%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

267 mg (0.7 mmol) of stereochemically pure transor cis-N-benzylazetidine-2,4-dicarboxylic acid benzyl t-butyl ester, 50mg of 10% Pd/C, and 20 ml of methanol are hydrogenated under 3 atm of hydrogen in a Parr shaker for 4 hours. The catalyst is filtered off and thoroughly washed, and the solution evaporated to dryness and dried in vacuo to afford as off-white solids the trans- or cis-azetidine-2,4-dicarboxylic acid mono-t-butyl ester.

後処理

  1. filtrationThe catalyst is filtered off
  2. washthoroughly washed
  3. customthe solution evaporated to dryness
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-afaae5fc9f7d434c8312c4b985dcb563
出典データセット
uspto-grants-1991_02
特許番号
US04990504

反応ノート

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