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Dimethylacetamide → Ammonium Hydroxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylacetamide | HCID 31374 | — |
| 反応物 | Imidazo(4,5-b)pyridine | HCID 67504 | — |
| 反応物 | N,N-dicyclopentyl-5-(chloromethyl)-2-pyridinecarboxamide | HCID 20071627 | — |
| 生成物 | Ammonium Hydroxide | HCID 14923 | — |
| 生成物 | N,N-dicyclopentyl-6-(5H-imidazo[4,5-c]pyridin-5-yl-methyl)-3-pyridinecarboxamide | HCID 20071631 | — |
反応手順
To a stirred solution of imidazopyridine in dimethylacetamide under argon, N,N-dicyclopentyl-5-(chloromethyl)-2-pyridinecarboxamide is added in one portion. The reaction temperature is slowly raised to 80°-85° C. and stirred for 24-60 hr. The reaction flask is cooled to room temperature and the solvent is removed under reduced pressure at <45° C. The residue is triturated with excess dry ether and filtered. The crude product is chromatographed on silica gel using mixtures of CH2Cl2 :MeOH:NH4OH to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04990518 |
| 出典データセット | uspto-grants-1991_02 |
| ORD ID | ord-f4c7ff7eb9fd4c1581dfe127113601ae |
| 出典メモ | uspto-grants-1991_02 |