反应详情

To a stirred solution of imidazopyridine in dimethylacetamide under argon, N,N-dicyclopentyl-5-(chloromethyl)-2-pyridinecarboxamide is added in one portion. The reaction temperature is slowly raised to 80°-85° C. and stirred for 24-60 hr. The reaction flask is cooled to room temperature and the solvent is removed under reduced pressure at <45° C. The residue is triturated with excess dry ether and filtered. The crude product is chromatographed on silica gel using mixtures of CH2Cl2 :MeOH:NH4OH to give the title compound.

1. temperatureThe reaction temperature is slowly raised to 80°-85° C.
2. customthe solvent is removed under reduced pressure at <45° C
3. customThe residue is triturated with excess dry ether
4. filtrationfiltered
5. customThe crude product is chromatographed on silica gel using mixtures of CH2Cl2