Ethyl trans-4-azido-3-methoxy-1-piperidinecarboxylate → Ethyl trans-4-amino-3-methoxy-1-piperidinecarboxylate
反応式
[N:1]([C@@H:4]1[CH2:9][CH2:8][N:7]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:6][C@H:5]1[O:15][CH3:16])=[N+]=[N-].[H][H]>[Pd].CO>[NH2:1][C@@H:4]1[CH2:9][CH2:8][N:7]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:6][C@H:5]1[O:15][CH3:16]参加物
5
実験手順
A mixture of 15.6 parts of ethyl trans-4-azido-3-methoxy-1-piperidinecarboxylate and 200 parts of methanol was hydrogenated at normal pressure and at room temperature with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated in vacuo, yielding 13.8 parts (97.4%) of ethyl trans-4-amino-3-methoxy-1-piperidinecarboxylate as a residue (interm. 5).
後処理
- filtrationthe catalyst was filtered off
- customthe filtrate was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-afed1b3cc59e414a9f5917e0bd69902c
- 出典データセット
- uspto-grants-1991_02
- 特許番号
- US04990521
反応ノート
読み込み中…