Iodoethane → 3-Ethyl-1-(t-butyldimethylsilyl)-4-vinyl-2-azetidinone

HRID 981853ノート

反応式

HRID 981853 の反応式
[O:1]=[C:2]1[N:9]2[CH:4]([CH2:5][CH2:6]OC2(C)C)[CH:3]1[CH:12]([CH3:14])C.[Si:15](N1C(C=C)CC1=O)([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16].O=C1N2C(CCOC2(C)C)C1.C(I)C>>[CH2:12]([CH:3]1[CH:4]([CH:5]=[CH2:6])[N:9]([Si:15]([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16])[C:2]1=[O:1])[CH3:14]

参加物

5

反応物 4

HCID 6340IodoethaneHCID 12769229HCID 12769229、化合物HCID 130511448-Oxo-2,2-dimethyl-7alpha-isopropyl-3-oxa-1-azabicyclo[4.2.0]octaneHCID 140681691-(t-Butyldimethylsilyl)-4-vinyl-2-azetidinone

生成物 1

HCID 151373693-Ethyl-1-(t-butyldimethylsilyl)-4-vinyl-2-azetidinone

実験手順

Following the procedure for the preparation of 8-oxo-2,2-dimethyl-7α-isopropyl-3-oxa-1-azabicyclo[4.2.0]octane (Example 4a, above), except that an equivalent amount of 1-(t-butyl-dimethylsilyl)-4-vinyl-2-azetidinone is substituted for the 8-oxo-2,2-dimethyl-3-oxa-1-azabicyclo [4.2.0]octane of Example 4a and using ethyl iodide instead of isopropyl iodide, the title compound is obtained.

出典と根拠

ORDレコード
ord-59f01bbd4ab24fb382e9b996ab309c98
出典データセット
uspto-grants-1991_02
特許番号
US04992542

反応ノート

読み込み中…