Ethylamine → HCID 10334355、化合物

HRID 981909ノート

反応式

HRID 981909 の反応式
[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](Cl)=[C:7]([N+:16]([O-:18])=[O:17])[C:6]1=[O:19])[CH2:2][CH2:3][CH3:4].[CH2:20]([NH2:22])[CH3:21]>O1CCCC1>[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([NH:22][CH2:20][CH3:21])=[C:7]([N+:16]([O-:18])=[O:17])[C:6]1=[O:19])[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 2

HCID 6341EthylamineHCID 99709251-Butyl-4-chloro-3-nitroquinolin-2(1H)-one

生成物 1

HCID 10334355HCID 10334355、化合物収率 97%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

3.5 g (0.013 mole) of Compound d in Reference Example 4 was dissolved in 30 ml of tetrahydrofuran, and 8.0 ml (0.13 mole) of ethylamine was added with ice cooling, followed by stirring at room temperature overnight. The solvent was evaporated under reduced pressure and ice water was added to the residue. The precipitate was collected by filtration and dried, to afford 3.5 g of Compound e (97%).

後処理

  1. customThe solvent was evaporated under reduced pressure and ice water
  2. additionwas added to the residue
  3. filtrationThe precipitate was collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-0a6203f950c24f5d95988075bf034413
出典データセット
uspto-grants-1991_02
特許番号
US04994468

反応ノート

読み込み中…