Methylamine → 2(1H)-Quinolinone, 1-butyl-4-(methylamino)-3-nitro-

HRID 981910ノート

反応式

HRID 981910 の反応式
[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](Cl)=[C:7]([N+:16]([O-:18])=[O:17])[C:6]1=[O:19])[CH2:2][CH2:3][CH3:4].[CH3:20][NH2:21]>O1CCCC1>[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([NH:21][CH3:20])=[C:7]([N+:16]([O-:18])=[O:17])[C:6]1=[O:19])[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 2

HCID 6329MethylamineHCID 99709251-Butyl-4-chloro-3-nitroquinolin-2(1H)-one

生成物 1

HCID 100847802(1H)-Quinolinone, 1-butyl-4-(methylamino)-3-nitro-収率 87%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

11 g (0.039 mole) of Compound d obtained in Reference Example 4 was dissolved in 100 ml of tetrahydrofuran, and 30 ml (0.39 mole) of 40% methylamine was added with ice cooling, followed by stirring at room temperature for one hour. Then, the solvent was evaporated under reduced pressure, and water was added to the residues. The precipitate was collected by filtration and dried, to afford 9.2 g of Compound w (yield: 87%).

後処理

  1. customThen, the solvent was evaporated under reduced pressure, and water
  2. additionwas added to the residues
  3. filtrationThe precipitate was collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-f3f84304477a4b1daecbafdedaab4c43
出典データセット
uspto-grants-1991_02
特許番号
US04994468

反応ノート

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