Ammonium Chloride → HCID 9795016、化合物

HRID 981922ノート

反応式

HRID 981922 の反応式
C([O:3][C:4](=O)[CH2:5][O:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:20]=1[C:19]([NH2:21])=[C:18]1[C:13]([CH2:14][CH2:15][CH2:16][CH2:17]1)=[N:12]2)C.CC(C)([O-])C.[K+].[Cl-].[NH4+]>O1CCCC1>[NH:21]1[C:19]2=[C:18]3[C:13](=[N:12][C:11]4=[CH:10][CH:9]=[CH:8][C:7](=[C:20]24)[O:6][CH2:5][C:4]1=[O:3])[CH2:14][CH2:15][CH2:16][CH2:17]3

参加物

5

反応物 3

HCID 25517Ammonium ChlorideHCID 20068607Ethyl[(9-amino-1,2,3,4-tetrahydroacridin-8-yl)oxy]acetateHCID 23665647Potassium tert-butoxide

生成物 1

HCID 9795016HCID 9795016、化合物収率 82.7%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Ethyl[(9-amino-1,2,3,4-tetrahydroacridin-8-yl)oxy]acetate (14.50 g) was dissolved in dry tetrahydrofuran (350 ml) and potassium t-butoxide (6.0 g) was added. After stirring for 1 hr, 100 ml saturated ammonium chloride solution (100 ml) was added, and stirring was continued for 30 min. The reaction mixture was evaporated under reduced pressure. The solid was collected and washed with water to give 10.15 g (82.65%) of product, mp 201°-202° C.

後処理

  1. stirringstirring
  2. waitwas continued for 30 min
  3. customThe reaction mixture was evaporated under reduced pressure
  4. customThe solid was collected
  5. washwashed with water

出典と根拠

ORDレコード
ord-02b77890b806423999df7c807a01f23d
出典データセット
uspto-grants-1991_02
特許番号
US04994452

反応ノート

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