Carbon Dioxide → 1,3-Benzothiazole-2-carboxylic acid
反応式
C([Li])CCC.[S:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[CH:7]1.[C:15](=[O:17])=[O:16].O>O1CCCC1>[S:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[C:15]([OH:17])=[O:16]参加物
6
実験手順
A precooled (-78° C.) solution of 7.7 ml (19.2 mmol) of n-butyllithium in 50 ml of dry tetrahydrofuran was treated dropwise with 2.0 ml (18.3 mmol) of benzothiazole. After the addition was complete, the solution was poured into a mixture of excess dry ice in 100 ml of tetrahydrofuran. After being allowed to warm, the resulting solution was treated with water, washed with ether, acidified with HCl, and filtered to give a yellow solid. Digestion with boiling ether followed by filtration gave 1.55 g (47%) of the desired compound as a nearly white solid.
後処理
- additionAfter the addition
- temperatureto warm
- washwashed with ether
- filtrationfiltered
- customto give a yellow solid
- filtrationDigestion with boiling ether followed by filtration
出典と根拠
- ORDレコード
- ord-defdc355577a4f3f883df978a3b7f93a
- 出典データセット
- uspto-grants-1991_02
- 特許番号
- US04994477
反応ノート
読み込み中…