Carbon Dioxide → 1,3-Benzothiazole-2-carboxylic acid

HRID 982024

反応式

HRID 982024 の反応式
C([Li])CCC.[S:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[CH:7]1.[C:15](=[O:17])=[O:16].O>O1CCCC1>[S:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[C:15]([OH:17])=[O:16]

参加物

6

反応物 4

HCID 280Carbon DioxideHCID 962WaterHCID 7222BenzothiazoleHCID 178418339Butyllithium

生成物 1

HCID 5850531,3-Benzothiazole-2-carboxylic acid収率 47%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A precooled (-78° C.) solution of 7.7 ml (19.2 mmol) of n-butyllithium in 50 ml of dry tetrahydrofuran was treated dropwise with 2.0 ml (18.3 mmol) of benzothiazole. After the addition was complete, the solution was poured into a mixture of excess dry ice in 100 ml of tetrahydrofuran. After being allowed to warm, the resulting solution was treated with water, washed with ether, acidified with HCl, and filtered to give a yellow solid. Digestion with boiling ether followed by filtration gave 1.55 g (47%) of the desired compound as a nearly white solid.

後処理

  1. additionAfter the addition
  2. temperatureto warm
  3. washwashed with ether
  4. filtrationfiltered
  5. customto give a yellow solid
  6. filtrationDigestion with boiling ether followed by filtration

出典と根拠

ORDレコード
ord-defdc355577a4f3f883df978a3b7f93a
出典データセット
uspto-grants-1991_02
特許番号
US04994477

関連ノート

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