6-(2-Pyrimidinyl)-5-hexynol → 6-(Pyrimidin-2-YL)hexan-1-OL

HRID 982378ノート

反応式

HRID 982378 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[C:7]#[C:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13]>C(O)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13]

参加物

4

反応物 1

HCID 198767486-(2-Pyrimidinyl)-5-hexynol

生成物 1

HCID 198767736-(Pyrimidin-2-YL)hexan-1-OL収率 29.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒2 回

実験手順

A solution of 6-(2-pyrimidinyl)-5-hexynol (3.09 g) in ethanol (100 ml) was added to a pre-hydrogenated suspension of 10% palladium on charcoal (1.05 g) in ethanol (50 ml) and hydrogenated at room temperature and pressure, filtered and evaporated in vacuo. The residual oil was purified by FCC eluting with ether and System C (99:1-85:15) to give the title compound as a pale yellow oil (0.93 g).

後処理

  1. filtrationpressure, filtered
  2. customevaporated in vacuo
  3. customThe residual oil was purified by FCC
  4. washeluting with ether and System C (99:1-85:15)

出典と根拠

ORDレコード
ord-5fb41320c6b84a3eb9a37cbc3c192cfe
出典データセット
uspto-grants-1991_02
特許番号
US04996218

反応ノート

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