6-(Pyrimidin-5-YL)hex-5-YN-1-OL → 6-(Pyrimidin-5-yl)hexan-1-ol

HRID 982379ノート

反応式

HRID 982379 の反応式
[N:1]1[CH:6]=[C:5]([C:7]#[C:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1>C(O)C.[Pd]>[N:1]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1

参加物

4

反応物 1

HCID 139997526-(Pyrimidin-5-YL)hex-5-YN-1-OL

生成物 1

HCID 135575446-(Pyrimidin-5-yl)hexan-1-ol収率 93.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒2 回

実験手順

A solution of 6-(5-pyrimidinyl)-5-hexynol (3.52 g) in ethanol (20 ml) was added to a pre-hydrogenated suspension of 10% palladium on carbon (1 g) in ethanol (130 ml) and hydrogenated at room temperature and pressure. The mixture was filtered through hyflo and the filtrate evaporated in vacuo to give the title compound as a pale yellow oil (3.38 g).

後処理

  1. filtrationThe mixture was filtered through hyflo
  2. customthe filtrate evaporated in vacuo

出典と根拠

ORDレコード
ord-902d94ae0e6f475fb5fb49a5d36508f8
出典データセット
uspto-grants-1991_02
特許番号
US04996218

反応ノート

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