1,6-Dibromohexane → HCID 19876744、化合物

HRID 982383ノート

反応式

HRID 982383 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13].[Br:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]Br.[OH-].[Na+]>O.CCOCC>[Br:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:2]1[N:3]=[CH:4][CH:5]=[CH:6][N:1]=1

参加物

6

反応物 3

HCID 123681,6-DibromohexaneHCID 14798Sodium HydroxideHCID 198767736-(Pyrimidin-2-YL)hexan-1-OL

生成物 1

HCID 19876744HCID 19876744、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 2-pyrimidinehexanol (1.18 g), 1,6-dibromohexane (4 ml), 50% sodium hydroxide (4 ml) and TAB (100 mg) was vigorously stirred at room temperature for 17 h, then diluted with water (40 ml) and ether (50 ml). The organic phase was dried and evaporated in vacuo to an oil which was purified by FCC. Elution with hexane followed by hexane-ether (1:1) gave the title compound as a colourless oil (670 mg), t.l.c. (ether) Rf 0.24

後処理

  1. customThe organic phase was dried
  2. customevaporated in vacuo to an oil which
  3. customwas purified by FCC
  4. washElution with hexane

出典と根拠

ORDレコード
ord-cebf3741cb2a4691ac23c178a8be2009
出典データセット
uspto-grants-1991_02
特許番号
US04996218

反応ノート

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