1,6-Dibromohexane → 5-[6-[(6-Bromohexyl)oxy]hexyl]pyrimidine

HRID 982384ノート

反応式

HRID 982384 の反応式
[N:1]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH:4]=[N:3][CH:2]=1.[OH-].[Na+].[Br:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]Br>O.CCOCC>[Br:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][O:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:5]1[CH:6]=[N:1][CH:2]=[N:3][CH:4]=1

参加物

6

反応物 3

HCID 123681,6-DibromohexaneHCID 14798Sodium HydroxideHCID 135575446-(Pyrimidin-5-yl)hexan-1-ol

生成物 1

HCID 198767545-[6-[(6-Bromohexyl)oxy]hexyl]pyrimidine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 5-pyrimidinehexanol (1.82 g), 50% sodium hydroxide (6 ml), 1,6-dibromohexane (6 ml) and TAB (150 mg) was vigorously stirred at room temperature for 30 h then diluted with water (20 ml) and ether (25 ml). The organic phase was dried and evaporated in vacuo. The residue was purified by FCC eluting with hexane followed by hexane-ether (1:1) and ether, to give the title compound as a colourless liquid (2.21 g), t.l.c. (ether) Rf 0.35.

後処理

  1. customThe organic phase was dried
  2. customevaporated in vacuo
  3. customThe residue was purified by FCC
  4. washeluting with hexane

出典と根拠

ORDレコード
ord-385cdbf4a8c340ed90403123ae3429cc
出典データセット
uspto-grants-1991_02
特許番号
US04996218

反応ノート

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