[6-[(6-Bromohexyl)oxy]-1-hexynyl]pyrazine → [6-[(6-Bromohexyl)oxy]hexyl]pyrazine

HRID 982394ノート

反応式

HRID 982394 の反応式
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[C:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1>C(O)C.[Pd]>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1

参加物

4

反応物 1

HCID 19876775[6-[(6-Bromohexyl)oxy]-1-hexynyl]pyrazine

生成物 1

HCID 19876745[6-[(6-Bromohexyl)oxy]hexyl]pyrazine収率 87.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒2 回

実験手順

A solution of [6-[(6-bromohexyl)oxy]-1-hexynyl]pyrazine (2.76 g) in ethanol (70 ml) was added to a pre-hydrogenated suspension of 10% palladium on carbon (2.00 g) in ethanol (50 ml) and hydrogenated at room temperature and pressure for 11 h. The mixture was filtered through hyflo and evaporated in vaco to afford the title compound as a colourless oil (2.45 g), t.l.c. (ether) Rf 0.55.

後処理

  1. filtrationThe mixture was filtered through hyflo
  2. customevaporated in vaco

出典と根拠

ORDレコード
ord-cc2096fb3ade4213ba15a74485b96ba4
出典データセット
uspto-grants-1991_02
特許番号
US04996218

反応ノート

読み込み中…