Hydrochloric Acid → 5-(ethoxycarbonyl)-3-hydroxy-9-oxo-9H-xanthene-2-propanoic acid

HRID 982449ノート

反応式

HRID 982449 の反応式
C([O:3][C:4](=[O:36])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:9][C:8]=1[O:25]CCCCCCCCCC)C.[Cl-].[Al+3].[Cl-].[Cl-].C(Cl)(=O)[C:42](Cl)=[O:43].Cl>C(Cl)Cl>[CH2:23]([O:22][C:20]([C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:14]=1[O:13][C:10]1[CH:9]=[C:8]([OH:25])[C:7]([CH2:6][CH2:5][C:4]([OH:3])=[O:36])=[CH:12][C:11]=1[C:42]2=[O:43])=[O:21])[CH3:24]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 65578Oxalyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 157180622-(Decyloxy)-4-[2-(ethoxycarbonyl)phenoxy]benzenepropanoic acid ethyl ester

生成物 1

HCID 200677635-(ethoxycarbonyl)-3-hydroxy-9-oxo-9H-xanthene-2-propanoic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 0.7 g of 2-(decyloxy)-4-[2-(ethoxycarbonyl)phenoxy]benzenepropanoic acid ethyl ester in methylene chloride at room temperature were added 0.187 g of aluminum chloride followed by 0.122 ml of oxalyl chloride. After stirring for approximately 1 hour, the mixture was poured into a combination of ice and hydrochloric acid. After stirring for approximately 1 hour, the layers were separated and the organic layer was dried and concentrated in vacuo. The material was used without further purification in the subsequent reaction.

後処理

  1. stirringAfter stirring for approximately 1 hour
  2. customthe layers were separated
  3. customthe organic layer was dried
  4. concentrationconcentrated in vacuo
  5. customThe material was used without further purification in the subsequent reaction

出典と根拠

ORDレコード
ord-d61cf8980657401c93329b9fb9a85abe
出典データセット
uspto-grants-1991_02
特許番号
US04996230

反応ノート

読み込み中…