Hydrochloric Acid → 2-(4-ethoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic Acid

HRID 982640ノート

反応式

HRID 982640 の反応式
C[O:2][C:3]([C:5]1[C:6]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH3:22])=[CH:16][CH:15]=2)=[N:7][N:8]2[C:13]=1[CH:12]=[CH:11][CH:10]=[N:9]2)=[O:4].[OH-].[Na+].Cl>C(O)C>[CH2:21]([O:20][C:17]1[CH:18]=[CH:19][C:14]([C:6]2[C:5]([C:3]([OH:4])=[O:2])=[C:13]3[N:8]([N:9]=[CH:10][CH:11]=[CH:12]3)[N:7]=2)=[CH:15][CH:16]=1)[CH3:22]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 542755002-(4-ethoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic Acid Methyl Ester

生成物 1

HCID 225623382-(4-ethoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic Acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-(4-ethoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid methyl ester (1.2 g), ethanol (10 ml) and 2N sodium hydroxide (10 ml) was heated to 80° for 1.5 h. The mixture was allowed to cool and acidified to pH 1 with 2N hydrochloric acid. The title compound was isolated by filtration as a brown solid (716 mg, 63%).

後処理

  1. temperaturewas heated to 80° for 1.5 h
  2. temperatureto cool

出典と根拠

ORDレコード
ord-02247d0a45b849c5a7d5cd5b1ca83dcc
出典データセット
uspto-grants-2005_03
特許番号
US06861429B2

反応ノート

読み込み中…